5ICP
CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(5-methyl-imidazo[5,1-b][1,3,4]thiadiazol-2-yl)-methanone
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cyclin-dependent kinase 8 | polymer | 364 | 42552.2 | 1 | UniProt (P49336) Pfam (PF00069) In PDB | Homo sapiens (Human) | Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35 |
2 | B | Cyclin-C | polymer | 267 | 31656.2 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) In PDB | Homo sapiens (Human) | SRB11 homolog,hSRB11 |
3 | A | [(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl](5-methylimidazo[5,1-b][1,3,4]thiadiazol-2-yl)methanone | non-polymer | 346.8 | 1 | Chemie (69Z) | |||
4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
5 | A, B | FORMIC ACID | non-polymer | 46.0 | 9 | Chemie (FMT) | |||
6 | water | water | 18.0 | 222 | Chemie (HOH) |
Sequence modifications
A: 1 - 362 (UniProt: P49336)
B: 1 - 264 (UniProt: P24863)
PDB | External Database | Details |
---|---|---|
Asp -1 | - | expression tag |
Lys 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp -2 | - | expression tag |
Lys -1 | - | expression tag |
Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 74208.4 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 947.3 | |
All* | Total formula weight | 75155.7 |