5ICP

CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(5-methyl-imidazo[5,1-b][1,3,4]thiadiazol-2-yl)-methanone

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cyclin-dependent kinase 8	polymer	364	42552.2	1	UniProt (P49336) Pfam (PF00069) In PDB	Homo sapiens (Human)	Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35
2	B	Cyclin-C	polymer	267	31656.2	1	UniProt (P24863) Pfam (PF00134) Pfam (PF16899) In PDB	Homo sapiens (Human)	SRB11 homolog,hSRB11
3	A	[(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl](5-methylimidazo[5,1-b][1,3,4]thiadiazol-2-yl)methanone	non-polymer		346.8	1	Chemie (69Z)
4	A	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
5	A, B	FORMIC ACID	non-polymer		46.0	9	Chemie (FMT)
6		water	water		18.0	222	Chemie (HOH)

Sequence modifications

A: 1 - 362 (UniProt: P49336)

PDB	External Database	Details
Asp -1	-	expression tag
Lys 0	-	expression tag

B: 1 - 264 (UniProt: P24863)

PDB	External Database	Details
Asp -2	-	expression tag
Lys -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74208.4
Non-Polymers*	Number of molecules	13
	Total formula weight	947.3
All*	Total formula weight	75155.7

*Water molecules are not included.