5I94
Crystal structure of human glutaminase C in complex with the inhibitor UPGL-00019
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Glutaminase kidney isoform, mitochondrial | polymer | 539 | 59429.5 | 4 | UniProt (O94925) Pfam (PF17959) Pfam (PF04960) In PDB | Homo sapiens (Human) | GLS,K-glutaminase,L-glutamine amidohydrolase |
2 | A, B | 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide | non-polymer | 535.6 | 2 | Chemie (69V) |
Sequence modifications
A, B, C, D: 71 - 597 (UniProt: O94925)
PDB | External Database | Details |
---|---|---|
Met 59 | - | initiating methionine |
Arg 60 | - | expression tag |
Gly 61 | - | expression tag |
Ser 62 | - | expression tag |
His 63 | - | expression tag |
His 64 | - | expression tag |
His 65 | - | expression tag |
His 66 | - | expression tag |
His 67 | - | expression tag |
His 68 | - | expression tag |
Gly 69 | - | expression tag |
Ser 70 | - | expression tag |
Ala 267 | Val 268 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 237718.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1071.3 | |
All* | Total formula weight | 238789.4 |