5I94

Crystal structure of human glutaminase C in complex with the inhibitor UPGL-00019

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Glutaminase kidney isoform, mitochondrial	polymer	539	59429.5	4	UniProt (O94925) Pfam (PF17959) Pfam (PF04960)	Homo sapiens (Human)	GLS,K-glutaminase,L-glutamine amidohydrolase
2	E, F (A, B)	2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide	non-polymer		535.6	2	Chemie (69V)

Sequence modifications

A, B, C, D: 71 - 597 (UniProt: O94925)

PDB	External Database	Details
Met 59	-	initiating methionine
Arg 60	-	expression tag
Gly 61	-	expression tag
Ser 62	-	expression tag
His 63	-	expression tag
His 64	-	expression tag
His 65	-	expression tag
His 66	-	expression tag
His 67	-	expression tag
His 68	-	expression tag
Gly 69	-	expression tag
Ser 70	-	expression tag
Ala 267	Val 268	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	237718.1
Non-Polymers*	Number of molecules	2
	Total formula weight	1071.3
All*	Total formula weight	238789.4

*Water molecules are not included.