5I94
Crystal structure of human glutaminase C in complex with the inhibitor UPGL-00019
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004359 | molecular_function | glutaminase activity |
| A | 0006541 | biological_process | glutamine metabolic process |
| B | 0004359 | molecular_function | glutaminase activity |
| B | 0006541 | biological_process | glutamine metabolic process |
| C | 0004359 | molecular_function | glutaminase activity |
| C | 0006541 | biological_process | glutamine metabolic process |
| D | 0004359 | molecular_function | glutaminase activity |
| D | 0006541 | biological_process | glutamine metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue 69V A 601 |
| Chain | Residue |
| A | ARG316 |
| D | LYS319 |
| D | LEU320 |
| D | PHE321 |
| D | LEU322 |
| D | ASN323 |
| D | GLU324 |
| D | TYR393 |
| A | LYS319 |
| A | LEU320 |
| A | PHE321 |
| A | LEU322 |
| A | ASN323 |
| A | ASP326 |
| A | TYR393 |
| A | LYS397 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue 69V B 601 |
| Chain | Residue |
| A | LEU315 |
| B | LYS319 |
| B | LEU320 |
| B | PHE321 |
| B | LEU322 |
| B | ASN323 |
| B | TYR393 |
| C | LYS319 |
| C | PHE321 |
| C | LEU322 |
| C | ASN323 |
| C | TYR393 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP0, ECO:0007744|PDB:3VP1 |
| Chain | Residue | Details |
| A | SER285 | |
| B | TYR413 | |
| B | TYR465 | |
| B | VAL483 | |
| C | SER285 | |
| C | ASN334 | |
| C | GLU380 | |
| C | TYR413 | |
| C | TYR465 | |
| C | VAL483 | |
| D | SER285 | |
| A | ASN334 | |
| D | ASN334 | |
| D | GLU380 | |
| D | TYR413 | |
| D | TYR465 | |
| D | VAL483 | |
| A | GLU380 | |
| A | TYR413 | |
| A | TYR465 | |
| A | VAL483 | |
| B | SER285 | |
| B | ASN334 | |
| B | GLU380 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP1 |
| Chain | Residue | Details |
| A | ASN387 | |
| B | ASN387 | |
| C | ASN387 | |
| D | ASN387 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Cleavage; by MPP => ECO:0000250|UniProtKB:P13264 |
| Chain | Residue | Details |
| A | LEU71 | |
| B | LEU71 | |
| C | LEU71 | |
| D | LEU71 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:D3Z7P3 |
| Chain | Residue | Details |
| A | LYS129 | |
| A | LYS163 | |
| B | LYS129 | |
| B | LYS163 | |
| C | LYS129 | |
| C | LYS163 | |
| D | LYS129 | |
| D | LYS163 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS310 | |
| B | LYS310 | |
| C | LYS310 | |
| D | LYS310 |
