5I89
Crystal structure of the bromodomain of human CREBBP bound to the benzodiazepinone G02857790
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CREB-binding protein | polymer | 118 | 13992.0 | 1 | UniProt (Q92793) Pfam (PF00439) | Homo sapiens (Human) | |
| 2 | B (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 3 | C (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | D (A) | (4R)-6-(3-cyclopropyl-1-methyl-1H-indazol-5-yl)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one | non-polymer | 346.4 | 1 | Chemie (69B) | |||
| 5 | E (A) | water | water | 18.0 | 246 | Chemie (HOH) |
Sequence modifications
A: 1082 - 1197 (UniProt: Q92793)
| PDB | External Database | Details |
|---|---|---|
| Gly 1080 | - | expression tag |
| Ser 1081 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13992.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 445.5 | |
| All* | Total formula weight | 14437.6 |
