5I4N
Crystal Structure of the E596A V617F Mutant JAK2 Pseudokinase Domain Bound to Mg-ATP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase JAK2 | polymer | 290 | 33242.2 | 1 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
2 | A | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | water | water | 18.0 | 186 | Chemie (HOH) |
Sequence modifications
A: 535 - 816 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
Ala 596 | Glu 596 | engineered mutation |
Phe 617 | Val 617 | engineered mutation |
Ala 659 | Trp 659 | engineered mutation |
Ala 777 | Trp 777 | engineered mutation |
His 794 | Phe 794 | engineered mutation |
Leu 817 | - | expression tag |
Val 818 | - | expression tag |
Pro 819 | - | expression tag |
Arg 820 | - | expression tag |
Gly 821 | - | expression tag |
Ser 822 | - | expression tag |
His 823 | - | expression tag |
His 824 | - | expression tag |
His 825 | - | expression tag |
His 826 | - | expression tag |
His 827 | - | expression tag |
His 828 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 33242.2 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 623.6 | |
All* | Total formula weight | 33865.7 |