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5I4N

Crystal Structure of the E596A V617F Mutant JAK2 Pseudokinase Domain Bound to Mg-ATP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues29
Detailsbinding site for residue ATP A 1000
ChainResidue
AGLY554
AVAL629
ASER633
AASN673
ALYS677
AASN678
ALEU680
AMG1001
AHOH1101
AHOH1122
AHOH1133
ATHR555
AHOH1143
AHOH1151
AHOH1152
AHOH1153
AHOH1164
AHOH1179
AHOH1192
AHOH1200
AHOH1208
AHOH1245
ATHR557
AILE559
ALEU579
ALYS581
AGLN626
AGLU627
APHE628

site_idAC2
Number of Residues4
Detailsbinding site for residue MG A 1001
ChainResidue
AASN678
AATP1000
AHOH1151
AHOH1192

site_idAC3
Number of Residues7
Detailsbinding site for residue GOL A 1002
ChainResidue
AARG715
ATRP718
ALYS752
AHOH1103
AHOH1121
AHOH1131
AHOH1179

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Breakpoint for translocation to form PCM1-JAK2 fusion protein
ChainResidueDetails
AASP710

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATYR570

220113

PDB entries from 2024-05-22

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