5I4H
Caught in the Act: The Crystal Structure of cleaved Cathepsin L bound to the active site of Cathepsin L
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cathepsin L1 | polymer | 106 | 11675.6 | 1 | UniProt (P07711) Pfam (PF00112) | Homo sapiens (Human) | Cathepsin L,Major excreted protein,MEP |
| 2 | B (B) | Cathepsin L1 | polymer | 112 | 12332.8 | 1 | UniProt (P07711) Pfam (PF00112) | Homo sapiens (Human) | Cathepsin L,Major excreted protein,MEP |
| 3 | C, D, F, G (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | E, H (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 246 | Chemie (HOH) |
Sequence modifications
A: -1 - 105 (UniProt: P07711)
B: 109 - 220 (UniProt: P07711)
| PDB | External Database | Details |
|---|---|---|
| Ser 25 | Cys 138 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 110 | Thr 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 24008.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 568.4 | |
| All* | Total formula weight | 24576.8 |
