5HZW

Crystal structure of the orphan region of human endoglin/CD105 in complex with BMP9

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Maltose-binding periplasmic protein,Endoglin	polymer	691	75141.2	1	UniProt (P0AEX9) UniProt (P17813) Pfam (PF01547)	Escherichia coli K12	MBP,MMBP,Maltodextrin-binding protein
2	B (B)	Growth/differentiation factor 2	polymer	110	12103.0	1	UniProt (Q9UK05) Pfam (PF00019)	Homo sapiens (Human)	GDF-2,Bone morphogenetic protein 9,BMP-9
3	C (C)	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	1	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)		alpha-maltose
4	D, E (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A: 56 - 422 (UniProt: P0AEX9)

PDB	External Database	Details
Glu 47	-	expression tag
Thr 48	-	expression tag
Gly 49	-	expression tag
His 50	-	expression tag
His 51	-	expression tag
His 52	-	expression tag
His 53	-	expression tag
His 54	-	expression tag
His 55	-	expression tag
Thr 57	Ile 28	engineered mutation
Ala 137	Asp 108	engineered mutation
Ala 138	Lys 109	engineered mutation
Ala 227	Glu 198	engineered mutation
Ala 228	Asn 199	engineered mutation
His 270	Ala 241	engineered mutation
His 274	Lys 245	engineered mutation
Ala 294	Lys 265	engineered mutation
Val 367	Ala 338	engineered mutation
Val 372	Ile 343	engineered mutation
Ala 414	Glu 385	engineered mutation
Ala 417	Lys 388	engineered mutation
Ala 418	Asp 389	engineered mutation
Asn 422	Arg 393	engineered mutation
Ala 423	-	linker
Ala 424	-	linker
Ala 425	-	linker

A: 426 - 737 (UniProt: P17813)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	87244.1
Branched	Number of molecules	1
	Total formula weight	342.3
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	88028.8

*Water molecules are not included.