5HZV

Crystal structure of the zona pellucida module of human endoglin/CD105

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Maltose-binding periplasmic protein,Endoglin	polymer	626	68228.4	1	UniProt (P0AEX9) UniProt (P17813) Pfam (PF01547)	Escherichia coli (strain K12)	MBP,MMBP,Maltodextrin-binding protein
2	B (B)	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	1	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)		alpha-maltose
3	C (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	D (A)	water	water		18.0	15	Chemie (HOH)

Sequence modifications

A: 368 - 734 (UniProt: P0AEX9)

PDB	External Database	Details
Glu 364	-	expression tag
Thr 365	-	expression tag
Gly 366	-	expression tag
Thr 367	-	expression tag
Ala 449	Asp 108	engineered mutation
Ala 450	Lys 109	engineered mutation
Ala 539	Glu 198	engineered mutation
Ala 540	Asn 199	engineered mutation
His 582	Ala 241	engineered mutation
His 586	Lys 245	engineered mutation
Ala 606	Lys 265	engineered mutation
Val 679	Ala 338	engineered mutation
Val 684	Ile 343	engineered mutation
Ala 726	Glu 385	engineered mutation
Ala 729	Lys 388	engineered mutation
Ala 730	Asp 389	engineered mutation
Asn 734	Arg 393	engineered mutation
Ala 735	-	linker
Ala 736	-	linker
Ala 737	-	linker

A: 738 - 981 (UniProt: P17813)

PDB	External Database	Details
Leu 982	-	expression tag
Glu 983	-	expression tag
His 984	-	expression tag
His 985	-	expression tag
His 986	-	expression tag
His 987	-	expression tag
His 988	-	expression tag
His 989	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	68228.4
Branched	Number of molecules	1
	Total formula weight	342.3
Non-Polymers*	Number of molecules	1
	Total formula weight	92.1
All*	Total formula weight	68662.8

*Water molecules are not included.