5HY9
Glycosylated, disulfide-linked Knob-into-Hole Fc fragment
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Ig gamma-1 chain C region | polymer | 227 | 25682.1 | 1 | UniProt (P01857) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
2 | B | Ig gamma-1 chain C region | polymer | 227 | 25400.8 | 1 | UniProt (P01857) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
3 | C | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 1 | In PDB GlyTouCan (G22043WL) | |||
4 | D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1098.0 | 1 | In PDB GlyTouCan (G21146IK) | |||
5 | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence modifications
A: 221 - 447 (UniProt: P01857)
B: 221 - 447 (UniProt: P01857)
PDB | External Database | Details |
---|---|---|
Cys 354 | Ser 237 | engineered mutation |
Trp 366 | Thr 249 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Cys 349 | Tyr 232 | engineered mutation |
Ser 366 | Thr 249 | engineered mutation |
Ala 368 | Leu 251 | engineered mutation |
Val 407 | Tyr 290 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 51082.9 | |
Branched | Number of molecules | 2 |
Total formula weight | 2723.5 | |
All* | Total formula weight | 53806.4 |