5HVW
Monomeric IgG4 Fc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ig gamma-4 chain C region | polymer | 210 | 23899.9 | 1 | UniProt (P01861) Pfam (PF07654) | Homo sapiens (Human) | |
| 2 | B (B) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 1 | In PDB GlyTouCan (G27919IH) | |||
| 3 | C, D (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | F (A) | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
A: 235 - 444 (UniProt: P01861)
| PDB | External Database | Details |
|---|---|---|
| Phe 351 | Leu 231 | engineered mutation |
| Arg 366 | Thr 246 | engineered mutation |
| Lys 395 | Pro 275 | engineered mutation |
| Arg 405 | Phe 285 | engineered mutation |
| Glu 407 | Tyr 287 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23899.9 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1625.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 222.9 | |
| All* | Total formula weight | 25748.3 |
