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5HVH

Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory Nanobodies

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ACarboxypeptidase B2polymer40146080.21UniProt (Q96IY4)
Pfam (PF02244)
Pfam (PF00246)
In PDB
Homo sapiens (Human)Carboxypeptidase U,CPU,Plasma carboxypeptidase B,pCPB,Thrombin-activable fibrinolysis inhibitor,TAFI
2BVHH-a204polymer12814034.41Vicugna pacos (alpaca)nanobody
3CVHH-i83polymer12513706.01Vicugna pacos (alpaca)nanobody
4D, E, F2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.43In PDB
GlyTouCan (G42666HT)
5A2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.21Chemie (NAG)
6AZINC IONnon-polymer65.41Chemie (ZN)
Sequence modifications
A: 1 - 401 (UniProt: Q96IY4)
PDBExternal DatabaseDetails
Cys 305Ser 327engineered mutation
Ile 329Thr 351engineered mutation
Tyr 333His 355engineered mutation
Gln 335His 357engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight73820.6
BranchedNumber of molecules3
Total formula weight1273.2
Non-Polymers*Number of molecules2
Total formula weight286.6
All*Total formula weight75380.4
*Water molecules are not included.

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PDB entries from 2024-07-17

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