Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5HVH

Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory Nanobodies

Functional Information from GO Data
ChainGOidnamespacecontents
A0003331biological_processpositive regulation of extracellular matrix constituent secretion
A0004180molecular_functioncarboxypeptidase activity
A0004181molecular_functionmetallocarboxypeptidase activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0007596biological_processblood coagulation
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0009410biological_processresponse to xenobiotic stimulus
A0010757biological_processnegative regulation of plasminogen activation
A0030163biological_processprotein catabolic process
A0042730biological_processfibrinolysis
A0046872molecular_functionmetal ion binding
A0051918biological_processnegative regulation of fibrinolysis
A0070062cellular_componentextracellular exosome
A0071333biological_processcellular response to glucose stimulus
A0097421biological_processliver regeneration
A2000346biological_processnegative regulation of hepatocyte proliferation
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01379
ChainResidueDetails
AGLU363

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01379, ECO:0000269|PubMed:18559974, ECO:0000269|PubMed:20088943
ChainResidueDetails
AHIS159
AGLU162
AHIS288

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P00730
ChainResidueDetails
AARG217
AASN234
ASER289
ATYR341

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Cleavage; by thrombin
ChainResidueDetails
AARG302

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16445295, ECO:0000269|PubMed:18559974
ChainResidueDetails
AASN22
AASN51

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16445295, ECO:0000269|PubMed:18559974
ChainResidueDetails
AASN63

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16445295, ECO:0000269|PubMed:18559974, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22171320
ChainResidueDetails
AASN86

site_idSWS_FT_FI8
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:16445295
ChainResidueDetails
AASN219

222624

PDB entries from 2024-07-17

PDB statisticsPDBj update infoContact PDBjnumon