5HRT

Crystal structure of mouse autotaxin in complex with a DNA aptamer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	polymer	831	95757.4	1	UniProt (Q9R1E6) Pfam (PF01033) Pfam (PF01663) Pfam (PF01223) In PDB	Mus musculus (Mouse)	E-NPP 2,Autotaxin,Extracellular lysophospholipase D,LysoPLD
2	B	modified DNA (34-MER)	polymer	34	10730.0	1		Homo sapiens
3	C	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1235.1	1	In PDB GlyTouCan (G16404YH)
4	D	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
5	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	A, B	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
7	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
8	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
9	A	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
10	A	GLYCEROL	non-polymer		92.1	10	Chemie (GOL)
11		water	water		18.0	459	Chemie (HOH)

Sequence modifications

A: 36 - 858 (UniProt: Q9R1E6)

PDB	External Database	Details
-	Lys 571	deletion
-	Val 572	deletion
-	Glu 573	deletion
-	Pro 574	deletion
Ser 859	-	expression tag
Arg 860	-	expression tag
Glu 861	-	expression tag
Asn 862	-	expression tag
Leu 863	-	expression tag
Tyr 864	-	expression tag
Phe 865	-	expression tag
Gln 866	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	106487.4
Branched	Number of molecules	2
	Total formula weight	1983.8
Non-Polymers*	Number of molecules	17
	Total formula weight	1229.5
All*	Total formula weight	109700.6

*Water molecules are not included.