5HQP

Crystal structure of the ERp44-peroxiredoxin 4 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Peroxiredoxin-4	polymer	246	28007.5	2	UniProt (Q13162) Pfam (PF00578) Pfam (PF10417)	Homo sapiens (Human)	Antioxidant enzyme AOE372,AOE37-2,Peroxiredoxin IV,Prx-IV,Thioredoxin peroxidase AO372,Thioredoxin-dependent peroxide reductase A0372
2	C, D (C, D)	Endoplasmic reticulum resident protein 44	polymer	382	44185.6	2	UniProt (Q9BS26) Pfam (PF00085) Pfam (PF13848)	Homo sapiens (Human)	ERp44,Thioredoxin domain-containing protein 4
3	E, F, G (A, B, C)	water	water		18.0	27	Chemie (HOH)

Sequence modifications

A, B: 38 - 271 (UniProt: Q13162)

PDB	External Database	Details
Met 26	-	expression tag
Arg 27	-	expression tag
Gly 28	-	expression tag
Ser 29	-	expression tag
His 30	-	expression tag
His 31	-	expression tag
His 32	-	expression tag
His 33	-	expression tag
His 34	-	expression tag
His 35	-	expression tag
Gly 36	-	expression tag
Ser 37	-	expression tag
Ser 51	Cys 51	engineered mutation
Ser 124	Cys 124	engineered mutation
Glu 155	Thr 155	engineered mutation

C, D: 1 - 377 (UniProt: Q9BS26)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
Leu -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	144386.1
All*	Total formula weight	144386.1

*Water molecules are not included.