5HQP

Crystal structure of the ERp44-peroxiredoxin 4 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0007252	biological_process	I-kappaB phosphorylation
A	0007283	biological_process	spermatogenesis
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0008584	biological_process	male gonad development
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0030198	biological_process	extracellular matrix organization
A	0034774	cellular_component	secretory granule lumen
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0042802	molecular_function	identical protein binding
A	0045454	biological_process	cell redox homeostasis
A	0051604	biological_process	protein maturation
A	0051920	molecular_function	peroxiredoxin activity
A	0060090	molecular_function	molecular adaptor activity
A	0070062	cellular_component	extracellular exosome
A	0072593	biological_process	reactive oxygen species metabolic process
A	0098869	biological_process	cellular oxidant detoxification
A	0140313	molecular_function	molecular sequestering activity
A	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2000255	biological_process	negative regulation of male germ cell proliferation
B	0004601	molecular_function	peroxidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0007252	biological_process	I-kappaB phosphorylation
B	0007283	biological_process	spermatogenesis
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0008584	biological_process	male gonad development
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0030198	biological_process	extracellular matrix organization
B	0034774	cellular_component	secretory granule lumen
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0042802	molecular_function	identical protein binding
B	0045454	biological_process	cell redox homeostasis
B	0051604	biological_process	protein maturation
B	0051920	molecular_function	peroxiredoxin activity
B	0060090	molecular_function	molecular adaptor activity
B	0070062	cellular_component	extracellular exosome
B	0072593	biological_process	reactive oxygen species metabolic process
B	0098869	biological_process	cellular oxidant detoxification
B	0140313	molecular_function	molecular sequestering activity
B	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2000255	biological_process	negative regulation of male germ cell proliferation
C	0003756	molecular_function	protein disulfide isomerase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
C	0006457	biological_process	protein folding
C	0006986	biological_process	response to unfolded protein
C	0009100	biological_process	glycoprotein metabolic process
C	0009986	cellular_component	cell surface
C	0034976	biological_process	response to endoplasmic reticulum stress
C	0035580	cellular_component	specific granule lumen
C	0045454	biological_process	cell redox homeostasis
C	0070062	cellular_component	extracellular exosome
D	0003756	molecular_function	protein disulfide isomerase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
D	0006457	biological_process	protein folding
D	0006986	biological_process	response to unfolded protein
D	0009100	biological_process	glycoprotein metabolic process
D	0009986	cellular_component	cell surface
D	0034976	biological_process	response to endoplasmic reticulum stress
D	0035580	cellular_component	specific granule lumen
D	0045454	biological_process	cell redox homeostasis
D	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00014
Number of Residues	4
Details	ER_TARGET Endoplasmic reticulum targeting sequence. RDEL

Chain	Residue	Details
C	ARG374-LEU377

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	424
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"PubMed","id":"12059788","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21916849","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	49
Details	Region: {"description":"Interaction with ITPR1","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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