5HQ3
Stable, high-expression variant of human acetylcholinesterase
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Acetylcholinesterase | polymer | 548 | 61193.8 | 1 | UniProt (P22303) Pfam (PF00135) In PDB | Homo sapiens (Human) | AChE |
2 | B | Acetylcholinesterase | polymer | 549 | 61322.9 | 1 | UniProt (P22303) Pfam (PF00135) In PDB | Homo sapiens (Human) | AChE |
3 | A, B | O-ETHYLMETHYLPHOSPHONIC ACID ESTER GROUP | non-polymer | 124.1 | 2 | Chemie (VX) | Homo sapiens | ||
4 | A, B | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | Homo sapiens | ||
5 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 1 - 547 (UniProt: P22303)
B: 1 - 548 (UniProt: P22303)
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
Thr 12 | Val 43 | engineered mutation |
Thr 23 | Lys 54 | engineered mutation |
Val 42 | Met 73 | engineered mutation |
Arg 48 | Leu 79 | engineered mutation |
Trp 60 | Val 91 | engineered mutation |
Asn 67 | Ser 98 | engineered mutation |
Asn 91 | Glu 122 | engineered mutation |
Lys 109 | Thr 140 | engineered mutation |
Asn 110 | Ser 141 | engineered mutation |
Ala 112 | Thr 143 | engineered mutation |
Met 115 | Leu 146 | engineered mutation |
Ser 127 | Ala 158 | engineered mutation |
Arg 140 | Gln 171 | engineered mutation |
Thr 141 | Ala 172 | engineered mutation |
Val 144 | Thr 175 | engineered mutation |
Ile 187 | Val 218 | engineered mutation |
Ile 226 | Val 257 | engineered mutation |
Ala 234 | Gly 265 | engineered mutation |
Tyr 238 | Thr 269 | engineered mutation |
Ser 240 | Gly 271 | engineered mutation |
Arg 241 | Met 272 | engineered mutation |
Glu 242 | Gly 273 | engineered mutation |
Leu 249 | Thr 280 | engineered mutation |
Lys 253 | His 284 | engineered mutation |
Asn 275 | Thr 306 | engineered mutation |
Pro 278 | Ala 309 | engineered mutation |
Glu 280 | Val 311 | engineered mutation |
Pro 309 | Ser 340 | engineered mutation |
Asn 318 | Ala 349 | engineered mutation |
Lys 322 | His 353 | engineered mutation |
Asp 325 | Gln 356 | engineered mutation |
Asn 331 | Val 362 | engineered mutation |
Glu 357 | Ala 388 | engineered mutation |
Glu 361 | Ala 392 | engineered mutation |
Ile 378 | Val 409 | engineered mutation |
Lys 393 | Arg 424 | engineered mutation |
Asn 394 | Leu 425 | engineered mutation |
Asp 396 | Glu 427 | engineered mutation |
Ile 408 | Val 439 | engineered mutation |
Phe 414 | Leu 445 | engineered mutation |
Gln 416 | Gly 447 | engineered mutation |
Tyr 418 | Leu 449 | engineered mutation |
Asn 421 | Gln 452 | engineered mutation |
Ser 434 | Ala 465 | engineered mutation |
Pro 438 | Ser 469 | engineered mutation |
Glu 441 | Leu 472 | engineered mutation |
Lys 467 | Ala 498 | engineered mutation |
Arg 474 | Gln 505 | engineered mutation |
Asp 506 | Gly 537 | engineered mutation |
Glu 507 | Ala 538 | engineered mutation |
Lys 509 | Gln 540 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
Thr 12 | Val 43 | engineered mutation |
Thr 23 | Lys 54 | engineered mutation |
Val 42 | Met 73 | engineered mutation |
Arg 48 | Leu 79 | engineered mutation |
Trp 60 | Val 91 | engineered mutation |
Asn 67 | Ser 98 | engineered mutation |
Asn 91 | Glu 122 | engineered mutation |
Lys 109 | Thr 140 | engineered mutation |
Asn 110 | Ser 141 | engineered mutation |
Ala 112 | Thr 143 | engineered mutation |
Met 115 | Leu 146 | engineered mutation |
Ser 127 | Ala 158 | engineered mutation |
Arg 140 | Gln 171 | engineered mutation |
Thr 141 | Ala 172 | engineered mutation |
Val 144 | Thr 175 | engineered mutation |
Ile 187 | Val 218 | engineered mutation |
Ile 226 | Val 257 | engineered mutation |
Ala 234 | Gly 265 | engineered mutation |
Tyr 238 | Thr 269 | engineered mutation |
Ser 240 | Gly 271 | engineered mutation |
Arg 241 | Met 272 | engineered mutation |
Glu 242 | Gly 273 | engineered mutation |
Leu 249 | Thr 280 | engineered mutation |
Lys 253 | His 284 | engineered mutation |
Asn 275 | Thr 306 | engineered mutation |
Pro 278 | Ala 309 | engineered mutation |
Glu 280 | Val 311 | engineered mutation |
Pro 309 | Ser 340 | engineered mutation |
Asn 318 | Ala 349 | engineered mutation |
Lys 322 | His 353 | engineered mutation |
Asp 325 | Gln 356 | engineered mutation |
Asn 331 | Val 362 | engineered mutation |
Glu 357 | Ala 388 | engineered mutation |
Glu 361 | Ala 392 | engineered mutation |
Ile 378 | Val 409 | engineered mutation |
Lys 393 | Arg 424 | engineered mutation |
Asn 394 | Leu 425 | engineered mutation |
Asp 396 | Glu 427 | engineered mutation |
Ile 408 | Val 439 | engineered mutation |
Phe 414 | Leu 445 | engineered mutation |
Gln 416 | Gly 447 | engineered mutation |
Tyr 418 | Leu 449 | engineered mutation |
Asn 421 | Gln 452 | engineered mutation |
Ser 434 | Ala 465 | engineered mutation |
Pro 438 | Ser 469 | engineered mutation |
Glu 441 | Leu 472 | engineered mutation |
Lys 467 | Ala 498 | engineered mutation |
Arg 474 | Gln 505 | engineered mutation |
Asp 506 | Gly 537 | engineered mutation |
Glu 507 | Ala 538 | engineered mutation |
Lys 509 | Gln 540 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 122516.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 638.6 | |
All* | Total formula weight | 123155.3 |