5HNS

Structure of glycosylated NPC1 luminal domain C

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Niemann-Pick C1 protein	polymer	244	27952.0	2	UniProt (O15118) Pfam (PF22314) In PDB	Homo sapiens (Human)
2	C, E, F, G, H	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	5	In PDB GlyTouCan (G42666HT)	Homo sapiens
3	D	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G22573RC)	Homo sapiens
4	I	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
5	J	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)	Homo sapiens
6	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)	Homo sapiens
7	A, B	THIOCYANATE ION	non-polymer		58.1	4	Chemie (SCN)
8		water	water		18.0	44	Chemie (HOH)

Sequence modifications

A, B: 387 - 618 (UniProt: O15118)

PDB	External Database	Details
Glu 384	-	expression tag
Thr 385	-	expression tag
Gly 386	-	expression tag
Thr 619	-	expression tag
Gly 620	-	expression tag
Thr 621	-	expression tag
Leu 622	-	expression tag
Glu 623	-	expression tag
Val 624	-	expression tag
Leu 625	-	expression tag
Phe 626	-	expression tag
Gln 627	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	55904.1
Branched	Number of molecules	8
	Total formula weight	4368.1
Non-Polymers*	Number of molecules	5
	Total formula weight	453.5
All*	Total formula weight	60725.7

*Water molecules are not included.