5HNS
Structure of glycosylated NPC1 luminal domain C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Niemann-Pick C1 protein | polymer | 244 | 27952.0 | 2 | UniProt (O15118) Pfam (PF22314) | Homo sapiens (Human) | |
| 2 | C, E, F, G, H (C, E, F, G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | Homo sapiens | ||
| 3 | D (D) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | Homo sapiens | ||
| 4 | I (I) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 5 | J (J) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | Homo sapiens | ||
| 6 | K (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | Homo sapiens | ||
| 7 | L, M, N, O (A, B) | THIOCYANATE ION | non-polymer | 58.1 | 4 | Chemie (SCN) | |||
| 8 | P, Q (A, B) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A, B: 387 - 618 (UniProt: O15118)
| PDB | External Database | Details |
|---|---|---|
| Glu 384 | - | expression tag |
| Thr 385 | - | expression tag |
| Gly 386 | - | expression tag |
| Thr 619 | - | expression tag |
| Gly 620 | - | expression tag |
| Thr 621 | - | expression tag |
| Leu 622 | - | expression tag |
| Glu 623 | - | expression tag |
| Val 624 | - | expression tag |
| Leu 625 | - | expression tag |
| Phe 626 | - | expression tag |
| Gln 627 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 55904.1 | |
| Branched | Number of molecules | 8 |
| Total formula weight | 4368.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 453.5 | |
| All* | Total formula weight | 60725.7 |
