5HNI
CRYSTAL STRUCTURE OF CMET WT with compound 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (X, Y) | Hepatocyte growth factor receptor | polymer | 312 | 35306.9 | 2 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (Human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
| 2 | C, D (X, Y) | methyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1H-benzimidazol-2-yl)carbamate | non-polymer | 435.4 | 2 | Chemie (63B) | |||
| 3 | E, F (X, Y) | water | water | 18.0 | 379 | Chemie (HOH) |
Sequence modifications
X, Y: 1049 - 1360 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Phe 1194 | Tyr 1212 | conflict |
| Phe 1234 | Tyr 1252 | conflict |
| Asp 1235 | Tyr 1253 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70613.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 870.9 | |
| All* | Total formula weight | 71484.7 |
