5HNI

CRYSTAL STRUCTURE OF CMET WT with compound 3

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0004672	molecular_function	protein kinase activity
X	0004713	molecular_function	protein tyrosine kinase activity
X	0005524	molecular_function	ATP binding
X	0006468	biological_process	protein phosphorylation
Y	0004672	molecular_function	protein kinase activity
Y	0004713	molecular_function	protein tyrosine kinase activity
Y	0005524	molecular_function	ATP binding
Y	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 63B X 1401

Chain	Residue
X	ALA1108
X	ASP1222
X	ALA1226
X	PRO1158
X	TYR1159
X	MET1160
X	GLY1163
X	ASP1164
X	ARG1208
X	ASN1209
X	ALA1221

---

site_id	AC2
Number of Residues	12
Details	binding site for residue 63B Y 1401

Chain	Residue
Y	VAL1092
Y	ALA1108
Y	PRO1158
Y	TYR1159
Y	MET1160
Y	GLY1163
Y	ASP1164
Y	ARG1208
Y	ASN1209
Y	MET1211
Y	ASP1222
Y	ALA1226

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	27
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGHFGCVYhGtlldndgkkih.......CAVK

Chain	Residue	Details
X	ILE1084-LYS1110

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNCML

Chain	Residue	Details
X	PHE1200-LEU1212

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"12475979","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"12475979","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7513258","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"15735664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7513258","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---