5HNI

CRYSTAL STRUCTURE OF CMET WT with compound 3

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0004672	molecular_function	protein kinase activity
X	0004713	molecular_function	protein tyrosine kinase activity
X	0005524	molecular_function	ATP binding
X	0006468	biological_process	protein phosphorylation
Y	0004672	molecular_function	protein kinase activity
Y	0004713	molecular_function	protein tyrosine kinase activity
Y	0005524	molecular_function	ATP binding
Y	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 63B X 1401

Chain	Residue
X	ALA1108
X	ASP1222
X	ALA1226
X	PRO1158
X	TYR1159
X	MET1160
X	GLY1163
X	ASP1164
X	ARG1208
X	ASN1209
X	ALA1221

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site_id	AC2
Number of Residues	12
Details	binding site for residue 63B Y 1401

Chain	Residue
Y	VAL1092
Y	ALA1108
Y	PRO1158
Y	TYR1159
Y	MET1160
Y	GLY1163
Y	ASP1164
Y	ARG1208
Y	ASN1209
Y	MET1211
Y	ASP1222
Y	ALA1226

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	27
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGHFGCVYhGtlldndgkkih.......CAVK

Chain	Residue	Details
X	ILE1084-LYS1110

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNCML

Chain	Residue	Details
X	PHE1200-LEU1212

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
X	LEU1186
Y	LEU1186

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
X	VAL1066
Y	VAL1066

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
X	VAL1092
Y	VAL1092

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:12475979

Chain	Residue	Details
X	LEU1212
X	GLU1347
Y	LEU1212
Y	GLU1347

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12475979

Chain	Residue	Details
X	PHE1216
Y	PHE1216

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:1655790

Chain	Residue	Details
X	THR1217
Y	THR1217

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
X	VAL1271
Y	VAL1271

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:7513258

Chain	Residue	Details
X	SER1331
Y	SER1331

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:7513258

Chain	Residue	Details
X	SER1338
Y	SER1338

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