5HNB

CDK8-CYCC IN COMPLEX WITH [6-Hydroxy-3-(3-methyl-benzyl)-1H-indazol-5-yl]-((S)-3-hydroxy-pyrrolidin-1-yl)-methanone

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Cyclin-dependent kinase 8	polymer	370	43233.0	1	UniProt (P49336) Pfam (PF00069)	Homo sapiens (Human)	Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35
2	B (B)	Cyclin-C	polymer	266	31541.1	1	UniProt (P24863) Pfam (PF00134) Pfam (PF16899)	Homo sapiens (Human)	SRB11 homolog,hSRB11
3	C (A)	[6-hydroxy-3-(3-methylbenzyl)-1H-indazol-5-yl][(3S)-3-hydroxypyrrolidin-1-yl]methanone	non-polymer		351.4	1	Chemie (62M)
4	D, E, F, G, H... (A, B)	FORMIC ACID	non-polymer		46.0	6	Chemie (FMT)
5	I, J (B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
6	L, M (A, B)	water	water		18.0	131	Chemie (HOH)

Sequence modifications

A: 1 - 362 (UniProt: P49336)

PDB	External Database	Details
Asp -2	-	expression tag
Asp -1	-	expression tag
Lys 0	-	expression tag
Pro 363	-	expression tag
Pro 364	-	expression tag
Leu 365	-	expression tag
Lys 366	-	expression tag
Lys 367	-	expression tag

B: 1 - 264 (UniProt: P24863)

PDB	External Database	Details
Lys -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74774.2
Non-Polymers*	Number of molecules	9
	Total formula weight	751.7
All*	Total formula weight	75525.8

*Water molecules are not included.