5HMK

HDM2 in complex with a 3,3-Disubstituted Piperidine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	E3 ubiquitin-protein ligase Mdm2	polymer	109	12526.3	2	UniProt (Q00987) Pfam (PF02201)	Homo sapiens (Human)	Double minute 2 protein,Hdm2,Oncoprotein Mdm2,p53-binding protein Mdm2
2	C, D (A, B)	{4-[2-(2-hydroxyethoxy)phenyl]piperazin-1-yl}[(2R,3S)-2-propyl-3-[4-(trifluoromethyl)phenoxy]-1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-3-yl]methanone	non-polymer		708.7	2	Chemie (62Q)
3	E, F (A, B)	water	water		18.0	54	Chemie (HOH)

Sequence modifications

A, B: 17 - 125 (UniProt: Q00987)

PDB	External Database	Details
Tyr 55	Phe 61	engineered mutation
His 76	Tyr 82	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	25052.6
Non-Polymers*	Number of molecules	2
	Total formula weight	1417.4
All*	Total formula weight	26470.0

*Water molecules are not included.