5HMI
HDM2 in complex with a 3,3-Disubstituted Piperidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | E3 ubiquitin-protein ligase Mdm2 | polymer | 104 | 12002.9 | 2 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,p53-binding protein Mdm2 |
| 2 | C, E (A, B) | {4-[2-(2-hydroxyethoxy)phenyl]piperazin-1-yl}[(2R,3S)-2-propyl-1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}-3-{[5-(trifluoromethyl)thiophen-3-yl]oxy}piperidin-3-yl]methanone | non-polymer | 714.7 | 2 | Chemie (62T) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 108 | Chemie (HOH) |
Sequence modifications
A, B: 18 - 116 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gln 16 | - | expression tag |
| Ile 17 | - | expression tag |
| Tyr 55 | Phe 61 | engineered mutation |
| His 76 | Tyr 82 | engineered mutation |
| Ala 117 | - | expression tag |
| Gly 118 | - | expression tag |
| Ala 119 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 24005.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1525.5 | |
| All* | Total formula weight | 25531.3 |
