5HMH
HDM2 in complex with a 3,3-Disubstituted Piperidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | E3 ubiquitin-protein ligase Mdm2 | polymer | 101 | 11581.4 | 2 | UniProt (Q00987) Pfam (PF02201) In PDB | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,p53-binding protein Mdm2 |
| 2 | A, B | 4-[2-(4-{[(2R,3S)-2-propyl-1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}-3-{[5-(trifluoromethyl)thiophen-3-yl]oxy}piperidin-3-yl]carbonyl}piperazin-1-yl)phenoxy]butanoic acid | non-polymer | 756.8 | 2 | Chemie (62R) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence modifications
A, B: 21 - 116 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Ala 19 | - | expression tag |
| Ser 20 | - | expression tag |
| Tyr 55 | Phe 55 | engineered mutation |
| His 76 | Tyr 76 | engineered mutation |
| Ala 117 | - | expression tag |
| Gly 118 | - | expression tag |
| Ala 119 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 23162.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1609.6 | |
| All* | Total formula weight | 24772.3 |
