5HMH
HDM2 in complex with a 3,3-Disubstituted Piperidine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005634 | cellular_component | nucleus |
A | 0043066 | biological_process | negative regulation of apoptotic process |
A | 0051726 | biological_process | regulation of cell cycle |
B | 0005634 | cellular_component | nucleus |
B | 0043066 | biological_process | negative regulation of apoptotic process |
B | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | binding site for residue 62R A 201 |
Chain | Residue |
A | GLN24 |
A | HIS96 |
A | ILE99 |
A | TYR100 |
A | HOH337 |
B | LYS51 |
B | TYR55 |
B | 62R4000 |
B | HOH4120 |
A | LEU54 |
A | GLY58 |
A | ILE61 |
A | MET62 |
A | TYR67 |
A | GLN72 |
A | PHE91 |
A | VAL93 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 202 |
Chain | Residue |
A | LYS94 |
A | GLU95 |
A | HIS96 |
A | ARG97 |
A | HOH313 |
site_id | AC3 |
Number of Residues | 18 |
Details | binding site for residue 62R B 4000 |
Chain | Residue |
A | LYS51 |
A | 62R201 |
B | GLN24 |
B | LYS51 |
B | LEU54 |
B | GLY58 |
B | ILE61 |
B | TYR67 |
B | GLN72 |
B | PHE91 |
B | VAL93 |
B | HIS96 |
B | ILE99 |
B | TYR100 |
B | HOH4103 |
B | HOH4113 |
B | HOH4120 |
B | HOH4121 |