5HM0
Crystal structure of the first bromodomain of human BRD4 bound to benzoisoxazoloazepine 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 4 | polymer | 128 | 15126.3 | 1 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (Human) | Protein HUNK1 |
| 2 | B (A) | 6-(4-chlorophenyl)-1-methyl-4H-[1,2]oxazolo[5,4-d][2]benzazepine | non-polymer | 308.8 | 1 | Chemie (62V) | |||
| 3 | C (A) | water | water | 18.0 | 112 | Chemie (HOH) |
Sequence modifications
A: 42 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Gly 41 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15126.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 308.8 | |
| All* | Total formula weight | 15435.1 |
