5HLY

Structure of Pro-Activin A Precursor at 2.3 A Resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Inhibin beta A chain	polymer	383	43664.0	1	UniProt (P08476) Pfam (PF00688) Pfam (PF00019) In PDB	Homo sapiens (Human)	Activin beta-A chain,Erythroid differentiation protein,EDF,Pro-Activin A
2	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
3		water	water		18.0	25	Chemie (HOH)

Sequence modifications

A: 30 - 426 (UniProt: P08476)

PDB	External Database	Details
Mse 20	-	initiating methionine
Ser 21	-	expression tag
His 22	-	expression tag
His 23	-	expression tag
His 24	-	expression tag
His 25	-	expression tag
His 26	-	expression tag
His 27	-	expression tag
Ser 28	-	expression tag
Mse 29	-	expression tag
Ser 35	Cys 35	engineered mutation
Ser 38	Cys 38	engineered mutation
-	Lys 259	deletion
-	Lys 260	deletion
-	Lys 261	deletion
-	Lys 262	deletion
-	Lys 263	deletion
-	Glu 264	deletion
-	Glu 265	deletion
-	Glu 266	deletion
-	Gly 267	deletion
-	Glu 268	deletion
-	Gly 269	deletion
-	Lys 270	deletion
-	Lys 271	deletion
-	Lys 272	deletion
-	Gly 273	deletion
-	Gly 274	deletion
-	Gly 275	deletion
-	Glu 276	deletion
-	Gly 277	deletion
-	Gly 278	deletion
-	Ala 279	deletion
-	Gly 280	deletion
-	Ala 281	deletion
-	Asp 282	deletion

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	43664.0
Non-Polymers*	Number of molecules	1
	Total formula weight	35.5
All*	Total formula weight	43699.5

*Water molecules are not included.