5HLY

Structure of Pro-Activin A Precursor at 2.3 A Resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001541	biological_process	ovarian follicle development
A	0001707	biological_process	mesoderm formation
A	0001942	biological_process	hair follicle development
A	0002244	biological_process	hematopoietic progenitor cell differentiation
A	0005102	molecular_function	signaling receptor binding
A	0005125	molecular_function	cytokine activity
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006366	biological_process	transcription by RNA polymerase II
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006914	biological_process	autophagy
A	0006952	biological_process	defense response
A	0007166	biological_process	cell surface receptor signaling pathway
A	0007267	biological_process	cell-cell signaling
A	0007399	biological_process	nervous system development
A	0008083	molecular_function	growth factor activity
A	0008202	biological_process	steroid metabolic process
A	0008209	biological_process	androgen metabolic process
A	0008285	biological_process	negative regulation of cell population proliferation
A	0008584	biological_process	male gonad development
A	0009611	biological_process	response to wounding
A	0010467	biological_process	gene expression
A	0010628	biological_process	positive regulation of gene expression
A	0017046	molecular_function	peptide hormone binding
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0021773	biological_process	striatal medium spiny neuron differentiation
A	0030154	biological_process	cell differentiation
A	0030218	biological_process	erythrocyte differentiation
A	0030308	biological_process	negative regulation of cell growth
A	0032689	biological_process	negative regulation of type II interferon production
A	0032924	biological_process	activin receptor signaling pathway
A	0032967	biological_process	positive regulation of collagen biosynthetic process
A	0035987	biological_process	endodermal cell differentiation
A	0042326	biological_process	negative regulation of phosphorylation
A	0042476	biological_process	odontogenesis
A	0042541	biological_process	hemoglobin biosynthetic process
A	0042701	biological_process	progesterone secretion
A	0042802	molecular_function	identical protein binding
A	0043509	cellular_component	activin A complex
A	0043512	cellular_component	inhibin A complex
A	0044877	molecular_function	protein-containing complex binding
A	0045578	biological_process	negative regulation of B cell differentiation
A	0045648	biological_process	positive regulation of erythrocyte differentiation
A	0045650	biological_process	negative regulation of macrophage differentiation
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0045945	biological_process	positive regulation of transcription by RNA polymerase III
A	0046880	biological_process	regulation of follicle-stimulating hormone secretion
A	0046881	biological_process	positive regulation of follicle-stimulating hormone secretion
A	0046882	biological_process	negative regulation of follicle-stimulating hormone secretion
A	0048333	biological_process	mesodermal cell differentiation
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051247	biological_process	positive regulation of protein metabolic process
A	0060008	biological_process	Sertoli cell differentiation
A	0060021	biological_process	roof of mouth development
A	0060279	biological_process	positive regulation of ovulation
A	0060391	biological_process	positive regulation of SMAD protein signal transduction
A	0060395	biological_process	SMAD protein signal transduction
A	0060936	biological_process	cardiac fibroblast cell development
A	0061029	biological_process	eyelid development in camera-type eye
A	0061370	biological_process	testosterone biosynthetic process
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0070699	molecular_function	type II activin receptor binding
A	0071372	biological_process	cellular response to follicle-stimulating hormone stimulus
A	0071397	biological_process	cellular response to cholesterol
A	0071456	biological_process	cellular response to hypoxia
A	0090650	biological_process	cellular response to oxygen-glucose deprivation
A	0097154	biological_process	GABAergic neuron differentiation
A	0097191	biological_process	extrinsic apoptotic signaling pathway
A	0150005	cellular_component	enzyme activator complex
A	1903449	biological_process	androst-4-ene-3,17-dione biosynthetic process
A	1904044	biological_process	response to aldosterone
A	1904385	biological_process	cellular response to angiotensin
A	2000134	biological_process	negative regulation of G1/S transition of mitotic cell cycle
A	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue CL A 501

Chain	Residue
A	ARG71
A	TRP335

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Functional Information from PROSITE/UniProt

site_id	PS00250
Number of Residues	16
Details	TGF_BETA_1 TGF-beta family signature. IiaPsgYhanyCeGeC

Chain	Residue	Details
A	ILE339-CYS354

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN165

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