5HKY
Crystal structure of c-Cbl TKBD domain in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8A Resolution (P6 form)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | E3 ubiquitin-protein ligase CBL | polymer | 308 | 35702.2 | 1 | UniProt (P22681) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) In PDB | Homo sapiens (Human) | Casitas B-lineage lymphoma proto-oncogene,Proto-oncogene c-Cbl,RING finger protein 55,Signal transduction protein CBL |
| 2 | B | Protein sprouty homolog 2 | polymer | 26 | 2992.2 | 1 | UniProt (O43597) In PDB | Homo sapiens | Spry-2 |
| 3 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | A | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 6 | water | water | 18.0 | 282 | Chemie (HOH) |
Sequence modifications
A: 47 - 351 (UniProt: P22681)
B: 36 - 60 (UniProt: O43597)
| PDB | External Database | Details |
|---|---|---|
| Ser 44 | - | expression tag |
| Asn 45 | - | expression tag |
| Ala 46 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ace 35 | - | acetylation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38694.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 332.2 | |
| All* | Total formula weight | 39026.6 |
