5HA6

Crystal structure of human syncytin-1 fusion subunit

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Syncytin-1	polymer	117	13317.9	2	UniProt (Q9UQF0)	Homo sapiens (Human)	Endogenous retrovirus group W member 1,Env-W,Envelope polyprotein gPr73,Enverin,HERV-7q Envelope protein,HERV-W envelope protein,HERV-W_7q21.2 provirus ancestral Env polyprotein,Syncytin
2	C, D (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
3	E, F (A, B)	water	water		18.0	73	Chemie (HOH)

Sequence modifications

A, B: 343 - 435 (UniProt: Q9UQF0)

PDB	External Database	Details
Met -23	-	initiating methionine
Ala -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
Val -15	-	expression tag
Asp -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Lys -10	-	expression tag
Met -9	-	expression tag
Leu -8	-	expression tag
Val -7	-	expression tag
Pro -6	-	expression tag
Arg -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Gly 0	-	expression tag
Ser 405	Cys 405	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	26635.8
Non-Polymers*	Number of molecules	2
	Total formula weight	70.9
All*	Total formula weight	26706.7

*Water molecules are not included.