5H7S
Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1 RING domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (E, F) | Ubiquitin-like 1 | polymer | 76 | 8576.8 | 2 | UniProt (P0CG47) Pfam (PF00240) | Homo sapiens (Human) | |
| 2 | B, E (D, B) | E3 ubiquitin-protein ligase LNX | polymer | 128 | 14625.9 | 2 | UniProt (Q8TBB1) Pfam (PF00097) | Homo sapiens (Human) | Ligand of Numb-protein X 1,Numb-binding protein 1,PDZ domain-containing RING finger protein 2,RING-type E3 ubiquitin transferase LNX |
| 3 | C, F (A, C) | Ubiquitin-conjugating enzyme E2 N | polymer | 152 | 17125.7 | 2 | UniProt (P61088) Pfam (PF00179) | Homo sapiens (Human) | Bendless-like ubiquitin-conjugating enzyme,E2 ubiquitin-conjugating enzyme N,Ubc13,UbcH13,Ubiquitin carrier protein N,Ubiquitin-protein ligase N |
| 4 | G, H, I, J, K... (D, B) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) |
Sequence modifications
A, C: 1 - 152 (UniProt: P61088)
| PDB | External Database | Details |
|---|---|---|
| Lys 87 | Cys 87 | engineered mutation |
| Ala 92 | Lys 92 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 80656.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 523.3 | |
| All* | Total formula weight | 81180.2 |
