5H6V
Structure of Zika virus protease in complex with a dipeptide inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Genome polyprotein | polymer | 52 | 5750.3 | 1 | UniProt (H8XX12) Pfam (PF01002) | Zika virus (ZIKV) | |
| 2 | B (B) | Genome polyprotein | polymer | 178 | 19009.6 | 1 | UniProt (H8XX12) Pfam (PF00949) | Zika virus (strain Mr 766) (ZIKV) | |
| 3 | C (B) | (S)-2-acetamido-6-amino-N-((S)-5-guanidino-1-oxopentan-2-yl)hexanamide | non-polymer | 328.4 | 1 | Chemie (7HS) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A: 45 - 95 (UniProt: H8XX12)
B: 1 - 177 (UniProt: H8XX12)
| PDB | External Database | Details |
|---|---|---|
| Met 44 | - | initiating methionine |
| - | Asp 1456 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Lys 29 | Arg 1525 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 24759.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 328.4 | |
| All* | Total formula weight | 25088.3 |
