5H5Q
Crystal structure of human GPX4 in complex with GXpep-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial | polymer | 169 | 19419.1 | 1 | UniProt (P36969) Pfam (PF00255) | Homo sapiens (Human) | PHGPx,Glutathione peroxidase 4,GSHPx-4 |
| 2 | B (B) | GXpep-1 | polymer | 15 | 1733.1 | 1 | Enterobacteria phage T7 | ||
| 3 | C, D (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 140 | Chemie (HOH) |
Sequence modifications
A: 29 - 197 (UniProt: P36969)
| PDB | External Database | Details |
|---|---|---|
| Ser 29 | Cys 29 | engineered mutation |
| Ala 37 | Cys 37 | engineered mutation |
| Ser 64 | Cys 64 | engineered mutation |
| Ocs 73 | Sec 73 | engineered mutation |
| Arg 93 | Cys 93 | engineered mutation |
| Ser 102 | Cys 102 | engineered mutation |
| Glu 134 | Cys 134 | engineered mutation |
| Val 175 | Cys 175 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21152.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 184.2 | |
| All* | Total formula weight | 21336.3 |
