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5H4D

Crystal structure of hSIRT3 in complex with a specific agonist Amiodarone hydrochloride

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, C
(A, H)
NAD-dependent protein deacetylase sirtuin-3, mitochondrialpolymer27130195.82UniProt (Q9NTG7)
Pfam (PF02146)
Homo sapiens (human)hSIRT3,Regulatory protein SIR2 homolog 3,SIR2-like protein 3
2B, D
(D, C)
ARG-HIS-LYSpolymer4612.72Homo sapiens
3E, K
(A, H)
ZINC IONnon-polymer65.42Chemie (ZN)
4F, M
(A, H)
MAGNESIUM IONnon-polymer24.32Chemie (MG)
5G, N
(A, H)
(2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanonenon-polymer645.32Chemie (BBI)
6H, O
(A, H)
NICOTINAMIDE-ADENINE-DINUCLEOTIDEnon-polymer663.42Chemie (NAD)
7I, P
(D, C)
7-AMINO-4-METHYL-CHROMEN-2-ONEnon-polymer175.22Chemie (MCM)
8J, L
(H)
DI(HYDROXYETHYL)ETHERnon-polymer106.12Chemie (PEG)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight61617.2
Non-Polymers*Number of molecules12
Total formula weight3359.5
All*Total formula weight64976.7
*Water molecules are not included.

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PDB entries from 2025-07-16

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