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5H4D

Crystal structure of hSIRT3 in complex with a specific agonist Amiodarone hydrochloride

Functional Information from GO Data
ChainGOidnamespacecontents
A0017136molecular_functionhistone deacetylase activity, NAD-dependent
A0051287molecular_functionNAD binding
A0070403molecular_functionNAD+ binding
H0017136molecular_functionhistone deacetylase activity, NAD-dependent
H0051287molecular_functionNAD binding
H0070403molecular_functionNAD+ binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 401
ChainResidue
ACYS256
ACYS259
ACYS280
ACYS283

site_idAC2
Number of Residues9
Detailsbinding site for residue BBI A 403
ChainResidue
DARG1
DHIS2
HPRO326
HSER329
APHE157
AARG158
AGLU177
APHE294
AVAL324

site_idAC3
Number of Residues17
Detailsbinding site for residue NAD A 404
ChainResidue
AGLY145
AALA146
AGLY147
ASER149
ATHR150
APHE157
AARG158
AGLN228
AASN229
AILE230
AASP231
AHIS248
AGLY319
ATHR320
ASER321
AASP365
AVAL366

site_idAC5
Number of Residues7
Detailsbinding site for residue PEG H 401
ChainResidue
HARG224
HALA241
HSER242
HLYS243
HLEU244
HVAL245
HARG301

site_idAC6
Number of Residues4
Detailsbinding site for residue ZN H 402
ChainResidue
HCYS256
HCYS259
HCYS280
HCYS283

site_idAC7
Number of Residues8
Detailsbinding site for residue BBI H 405
ChainResidue
APRO326
ASER329
CARG1
HARG158
HGLU177
HPHE294
HVAL324
HNAD406

site_idAC8
Number of Residues18
Detailsbinding site for residue NAD H 406
ChainResidue
HGLY145
HALA146
HGLY147
HSER149
HTHR150
HPRO151
HARG158
HGLN228
HASN229
HILE230
HASP231
HHIS248
HTHR320
HSER321
HASN344
HASP365
HVAL366
HBBI405

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12186850","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16788062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18794531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues54
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19535340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37720100","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19535340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8R104","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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