5GWY
Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | main protease | polymer | 308 | 33174.6 | 2 | UniProt (P0C6U6) Pfam (PF05409) | Human coronavirus NL63 (HCoV-NL63) | 3C-like proteinase |
| 2 | C, D (D, E) | N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE | polymer | 6 | 680.8 | 2 | BIRD (PRD_002214) | synthetic construct | |
| 3 | E, F, G, H (A, B, D, E) | water | water | 18.0 | 295 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 303 (UniProt: P0C6U6)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 67710.7 | |
| All* | Total formula weight | 67710.7 |
