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5GWY

Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
main proteasepolymer30833174.62UniProt (P0C6U6)
Pfam (PF05409)
Human coronavirus NL63 (HCoV-NL63)3C-like proteinase
2C, D
(D, E)
N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDEpolymer6680.82BIRD (PRD_002214)synthetic construct
3E, F, G, H
(A, B, D, E)
waterwater18.0295Chemie (HOH)
Sequence modifications
A, B: 1 - 303 (UniProt: P0C6U6)
PDBExternal DatabaseDetails
Gly -4-expression tag
Pro -3-expression tag
Leu -2-expression tag
Gly -1-expression tag
Ser 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight67710.7
All*Total formula weight67710.7
*Water molecules are not included.

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PDB entries from 2024-11-06

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