5GWK
Human topoisomerase IIalpha in complex with DNA and etoposide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA topoisomerase 2-alpha | polymer | 806 | 92917.8 | 2 | UniProt (P11388) Pfam (PF01751) Pfam (PF16898) Pfam (PF00521) | Homo sapiens (Human) | DNA topoisomerase II,alpha isozyme |
| 2 | C, E (C, E) | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3') | polymer | 8 | 2436.6 | 2 | synthetic construct | ||
| 3 | D, F (D, F) | DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3') | polymer | 12 | 3654.4 | 2 | synthetic construct | ||
| 4 | G, H, I, J, K... (A, B, D, F) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 5 | L, N (D, F) | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside | non-polymer | 588.6 | 2 | Chemie (EVP) |
Sequence modifications
A, B: 429 - 1188 (UniProt: P11388)
| PDB | External Database | Details |
|---|---|---|
| Met 403 | - | expression tag |
| Ala 404 | - | expression tag |
| Ser 405 | - | expression tag |
| Trp 406 | - | expression tag |
| Ser 407 | - | expression tag |
| His 408 | - | expression tag |
| Pro 409 | - | expression tag |
| Gln 410 | - | expression tag |
| Phe 411 | - | expression tag |
| Glu 412 | - | expression tag |
| Lys 413 | - | expression tag |
| Gly 414 | - | expression tag |
| Ala 415 | - | expression tag |
| Asp 416 | - | expression tag |
| Asp 417 | - | expression tag |
| Asp 418 | - | expression tag |
| Asp 419 | - | expression tag |
| Lys 420 | - | expression tag |
| Val 421 | - | expression tag |
| Pro 422 | - | expression tag |
| Asp 423 | - | expression tag |
| Pro 424 | - | expression tag |
| Thr 425 | - | expression tag |
| Ser 426 | - | expression tag |
| Val 427 | - | expression tag |
| Asp 428 | - | expression tag |
| Gly 1189 | - | expression tag |
| Ala 1190 | - | expression tag |
| Pro 1191 | - | expression tag |
| Gly 1192 | - | expression tag |
| Phe 1193 | - | expression tag |
| Ser 1194 | - | expression tag |
| Ser 1195 | - | expression tag |
| Ile 1196 | - | expression tag |
| Ser 1197 | - | expression tag |
| Ala 1198 | - | expression tag |
| His 1199 | - | expression tag |
| His 1200 | - | expression tag |
| His 1201 | - | expression tag |
| His 1202 | - | expression tag |
| His 1203 | - | expression tag |
| His 1204 | - | expression tag |
| His 1205 | - | expression tag |
| His 1206 | - | expression tag |
| His 1207 | - | expression tag |
| His 1208 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 198017.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1322.9 | |
| All* | Total formula weight | 199340.4 |
