Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006265 | biological_process | DNA topological change |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 1301 |
| Chain | Residue |
| A | ASP541 |
| A | ASP543 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 1302 |
| Chain | Residue |
| A | ASN851 |
| A | GLU854 |
| A | ARG929 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 1301 |
| Chain | Residue |
| B | ASP541 |
| B | ASP543 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 1302 |
| Chain | Residue |
| B | ASN851 |
| B | ARG929 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue MG D 101 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue EVP D 102 |
| Chain | Residue |
| B | GLY462 |
| B | ASP463 |
| B | ARG487 |
| B | MET766 |
| D | DA12 |
| D | DG13 |
| E | DC8 |
| F | DT9 |
| F | DG10 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue MG F 101 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue EVP F 102 |
| Chain | Residue |
| A | GLY462 |
| A | ASP463 |
| A | ARG487 |
| A | MET762 |
| A | MET766 |
| C | DC8 |
| D | DT9 |
| D | DG10 |
| F | DA12 |
| F | DG13 |
Functional Information from PROSITE/UniProt
| site_id | PS00177 |
| Number of Residues | 9 |
| Details | TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSAKT |
| Chain | Residue | Details |
| A | LEU459-THR467 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | TYR805 | |
| B | TYR805 | |
| Chain | Residue | Details |
| A | GLU461 | |
| B | GLU461 | |
| Chain | Residue | Details |
| A | ASP541 | |
| A | ASP543 | |
| B | ASP541 | |
| B | ASP543 | |
| Chain | Residue | Details |
| A | LYS489 | |
| B | LYS489 | |
| Chain | Residue | Details |
| A | ASN492 | |
| B | LYS662 | |
| B | LYS723 | |
| B | TYR757 | |
| B | SER763 | |
| B | TRP931 | |
| A | ARG661 | |
| A | LYS662 | |
| A | LYS723 | |
| A | TYR757 | |
| A | SER763 | |
| A | TRP931 | |
| B | ASN492 | |
| B | ARG661 | |
| Chain | Residue | Details |
| A | ARG804 | |
| B | ARG804 | |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Important for DNA bending; intercalates between base pairs of target DNA => ECO:0000250|UniProtKB:P06786 |
| Chain | Residue | Details |
| A | ILE856 | |
| B | ILE856 | |
| Chain | Residue | Details |
| A | SER1106 | |
| B | SER1106 | |
| site_id | SWS_FT_FI9 |
| Number of Residues | 26 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS440 | |
| A | LYS625 | |
| A | LYS632 | |
| A | LYS655 | |
| A | LYS1114 | |
| B | LYS440 | |
| B | LYS466 | |
| B | LYS480 | |
| B | LYS529 | |
| B | LYS584 | |
| B | LYS599 | |
| B | LYS614 | |
| B | LYS622 | |
| B | LYS625 | |
| B | LYS632 | |
| B | LYS655 | |
| B | LYS1114 | |
| A | LYS466 | |
| A | LYS480 | |
| A | LYS529 | |
| A | LYS584 | |
| A | LYS599 | |
| A | LYS614 | |
| A | LYS622 | |
| Chain | Residue | Details |
| A | LYS639 | |
| A | LYS662 | |
| A | LYS676 | |
| A | LYS1075 | |
| B | LYS639 | |
| B | LYS662 | |
| B | LYS676 | |
| B | LYS1075 | |
