5GTJ

CRYSTAL STRUCTURE OF CATALYTICALLY ACTIVE FORM OF HUMAN DUSP26

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Dual specificity protein phosphatase 26	polymer	181	20685.7	4	UniProt (Q9BV47) Pfam (PF00782)	Homo sapiens (Human)	Dual specificity phosphatase SKRP3,Low-molecular-mass dual-specificity phosphatase 4,LDP-4,Mitogen-activated protein kinase phosphatase 8,MKP-8,Novel amplified gene in thyroid anaplastic cancer
2	E, F, G, H (A, B, C, D)	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
3	I, J, K, L (A, B, C, D)	water	water		18.0	477	Chemie (HOH)

Sequence modifications

A, B, C, D: 39 - 211 (UniProt: Q9BV47)

PDB	External Database	Details
Ser 152	Cys 152	engineered mutation
Leu 212	-	expression tag
Glu 213	-	expression tag
His 214	-	expression tag
His 215	-	expression tag
His 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	82742.7
Non-Polymers*	Number of molecules	4
	Total formula weight	379.9
All*	Total formula weight	83122.6

*Water molecules are not included.