5GP1
Crystal structure of ZIKV NS5 Methyltransferase in complex with GTP and SAH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | RNA-directed RNA polymerase NS5 | polymer | 269 | 29711.9 | 3 | UniProt (H9A910) Pfam (PF01728) UniProt (by SIFTS) (A0A024B7W1) | Zika virus (ZIKV) | NS5 Methyltransferase |
| 2 | D, E, F, G, H... (A, B, C) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 3 | I, M, Q (A, B, C) | P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE | non-polymer | 787.4 | 3 | Chemie (GTA) | |||
| 4 | J, N, R (A, B, C) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 3 | Chemie (SAH) | |||
| 5 | P (C) | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
| 6 | S, T, U (A, B, C) | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A, B, C: 4 - 265 (UniProt: H9A910)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Val 2 | - | expression tag |
| Asp 3 | - | expression tag |
| Ala 266 | - | expression tag |
| Ala 267 | - | expression tag |
| Ser 268 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 89135.7 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 4342.8 | |
| All* | Total formula weight | 93478.5 |
