5GOZ
Crystal structure of ZIKV NS5 Methyltransferase in complex with GTP and SAH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | RNA-directed RNA polymerase NS5 | polymer | 269 | 29711.9 | 3 | UniProt (H9A910) UniProt (by SIFTS) (A0A024B7W1) | Zika virus (strain Mr 766) (ZIKV) | NS5 Methyltransferase |
| 2 | D, H, N, O (A, B, C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 4 | Chemie (GTP) PubChem (135600366) PubChem (135749822) PubChem (136664747) PubChem (136803486) PubChem (164715984) PubChem (135398633) PubChem (135400627) PubChem (135487750) PubChem (135544356) PubChem (135547949) PubChem (136005188) PubChem (136073923) PubChem (136088935) PubChem (136240914) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (171699466) | |||
| 3 | E, I, P (A, B, C) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 3 | Chemie (SAH) PubChem (118560068) PubChem (126969526) PubChem (189149) PubChem (13792) PubChem (163054214) PubChem (439155) PubChem (118374891) PubChem (5284331) PubChem (6419189) PubChem (129105892) PubChem (13231890) PubChem (16760024) PubChem (21125603) PubChem (143518505) PubChem (154578335) PubChem (25203782) PubChem (25210495) PubChem (44361184) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (163335525) PubChem (164157219) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70832431) PubChem (71170554) PubChem (193) PubChem (52224400) PubChem (57544532) PubChem (59046843) PubChem (70702054) | |||
| 4 | F, G, L, M, S (A, B, C) | PHOSPHATE ION | non-polymer | 95.0 | 5 | Chemie (PO4) PubChem (1061) | |||
| 5 | J, K, Q (B, C) | SUCCINIC ACID | non-polymer | 118.1 | 3 | Chemie (SIN) PubChem (1110) | |||
| 6 | R (C) | PYROPHOSPHATE 2- | non-polymer | 176.0 | 1 | Chemie (POP) PubChem (4995) | |||
| 7 | T, U, V (A, B, C) | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence modifications
A, B, C: 4 - 265 (UniProt: H9A910)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Val 2 | - | expression tag |
| Asp 3 | - | expression tag |
| Ala 266 | - | expression tag |
| Ala 267 | - | expression tag |
| Ser 268 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 89135.7 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 4251.0 | |
| All* | Total formula weight | 93386.8 |
