5GOZ
Crystal structure of ZIKV NS5 Methyltransferase in complex with GTP and SAH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | RNA-directed RNA polymerase NS5 | polymer | 269 | 29711.9 | 3 | UniProt (H9A910) Pfam (PF01728) UniProt (by SIFTS) (A0A024B7W1) | Zika virus (strain Mr 766) (ZIKV) | NS5 Methyltransferase |
| 2 | D, H, N, O (A, B, C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 4 | Chemie (GTP) | |||
| 3 | E, I, P (A, B, C) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 3 | Chemie (SAH) | |||
| 4 | F, G, L, M, S (A, B, C) | PHOSPHATE ION | non-polymer | 95.0 | 5 | Chemie (PO4) | |||
| 5 | J, K, Q (B, C) | SUCCINIC ACID | non-polymer | 118.1 | 3 | Chemie (SIN) | |||
| 6 | R (C) | PYROPHOSPHATE 2- | non-polymer | 176.0 | 1 | Chemie (POP) | |||
| 7 | T, U, V (A, B, C) | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence modifications
A, B, C: 4 - 265 (UniProt: H9A910)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Val 2 | - | expression tag |
| Asp 3 | - | expression tag |
| Ala 266 | - | expression tag |
| Ala 267 | - | expression tag |
| Ser 268 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 89135.7 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 4251.0 | |
| All* | Total formula weight | 93386.8 |
