5GMG

Crystal structure of monkey TLR7 in complex with loxoribine and polyU

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Toll-like receptor 7	polymer	817	94014.7	2	UniProt (B3Y653) Pfam (PF13855) In PDB	Macaca mulatta (Rhesus macaque)	Uncharacterized protein
2	C, D	RNA (5'-R(P*UP*UP*UP*U)-3')	polymer	4	1179.7	2		Homo sapiens
3	E, F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
5	B	2-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7-prop-2-enyl-1~{H}-purine-6,8-dione	non-polymer		339.3	2	Chemie (SDL)
6	B	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
7		water	water		18.0	33	Chemie (HOH)

Sequence modifications

A, B: 27 - 839 (UniProt: B3Y653)

PDB	External Database	Details
Arg 23	-	expression tag
Ser 24	-	expression tag
Pro 25	-	expression tag
Trp 26	-	expression tag
Gln 167	Asn 167	engineered mutation
Gln 389	Asn 389	engineered mutation
Gln 488	Asn 488	engineered mutation
Gln 799	Asn 799	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	190388.7
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	9
	Total formula weight	2100.8
All*	Total formula weight	193338.4

*Water molecules are not included.