5GMF
Crystal structure of monkey TLR7 in complex with guanosine and polyU
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Toll-like receptor 7 | polymer | 817 | 94014.7 | 4 | UniProt (B3Y653) Pfam (PF13855) | Macaca mulatta (Rhesus macaque) | Uncharacterized protein |
| 2 | E, F, G, H (E, F, G, H) | RNA (5'-R(P*UP*UP*UP*U)-3') | polymer | 4 | 1179.7 | 4 | Homo sapiens | ||
| 3 | I, J, K, L, M... (I, J, K, L, M...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 4 | HA, IA, O, T (D, A, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) PubChem (271) | |||
| 5 | AA, BA, CA, DA, EA... (C, D, A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) | |||
| 6 | GA, S, Y, Z (D, B, C) | GUANOSINE | non-polymer | 283.2 | 4 | Chemie (GMP) PubChem (135499520) PubChem (162360751) PubChem (135398635) PubChem (135402034) PubChem (135426840) PubChem (135440077) PubChem (135484501) PubChem (135508725) PubChem (135514572) PubChem (135538738) PubChem (135546397) PubChem (135699331) PubChem (135726185) PubChem (135768161) PubChem (135768162) PubChem (135796591) PubChem (135823787) PubChem (135976484) PubChem (136019960) PubChem (136029099) PubChem (136029343) PubChem (136032217) PubChem (136073062) PubChem (136073540) PubChem (136168113) PubChem (136200123) PubChem (136259572) PubChem (136263240) PubChem (136461600) PubChem (136474462) PubChem (136490162) PubChem (136594098) PubChem (136596777) PubChem (136612256) PubChem (136614128) PubChem (136835877) PubChem (136912867) PubChem (136996824) PubChem (137506101) PubChem (163824507) PubChem (166857379) PubChem (168265885) PubChem (173984522) | |||
| 7 | OA, PA, QA, RA (A, B, C, D) | water | water | 18.0 | 157 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 27 - 839 (UniProt: B3Y653)
| PDB | External Database | Details |
|---|---|---|
| Arg 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Pro 25 | - | expression tag |
| Trp 26 | - | expression tag |
| Gln 167 | Asn 167 | engineered mutation |
| Gln 389 | Asn 389 | engineered mutation |
| Gln 488 | Asn 488 | engineered mutation |
| Gln 799 | Asn 799 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 380777.4 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 2546.4 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 5275.0 | |
| All* | Total formula weight | 388598.9 |
