5GHW

Crystal structure of broad neutralizing antibody 10E8 with long epitope bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	FAB 10E8 HEAVY CHAIN	polymer	239	25648.7	1		Homo sapiens
2	B (L)	FAB 10E8 LIGHT CHAIN	polymer	216	23152.6	1		Homo sapiens
3	C (P)	Endogenous retrovirus group K member 8 Env polyprotein	polymer	36	4623.7	1	UniProt (G3DED6) UniProt (by SIFTS) (P04578)	Human immunodeficiency virus 1	Endogenous retrovirus group K member 113 Env polyprotein,Endogenous retrovirus group K member 13-1 Env polyprotein,Endogenous retrovirus group K member 18 Env polyprotein,Endogenous retrovirus group K member 19 Env polyprotein,Endogenous retrovirus group K member 21 Env polyprotein,Endogenous retrovirus group K member 24 Env polyprotein,Endogenous retrovirus group K member 25 Env polyprotein,Endogenous retrovirus group K member 6 Env polyprotein,Endogenous retrovirus group K member 7 Env polyprotein,Endogenous retrovirus group K member 9 Env polyprotein,Envelope glycoprotein gp160
4	D, E, F, G, H... (H, L)	PHOSPHATE ION	non-polymer		95.0	7	Chemie (PO4)
5	K, L (H, L)	water	water		18.0	132	Chemie (HOH)

Sequence modifications

P: 666 - 690 (UniProt: G3DED6)

PDB	External Database	Details
Lys 660	-	expression tag
Lys 661	-	expression tag
Lys 662	-	expression tag
Lys 663	-	expression tag
Asp 664	-	expression tag
Lys 665	-	expression tag
Lys 691	-	expression tag
Lys 692	-	expression tag
Lys 693	-	expression tag
Lys 694	-	expression tag
Lys 695	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	53425.0
Non-Polymers*	Number of molecules	7
	Total formula weight	664.8
All*	Total formula weight	54089.8

*Water molecules are not included.