5G53
Structure of the adenosine A2A receptor bound to an engineered G protein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | ADENOSINE RECEPTOR A2A | polymer | 314 | 34909.5 | 2 | UniProt (P29274) Pfam (PF00001) | HOMO SAPIENS (HUMAN) | |
| 2 | C, D (C, D) | ENGINEERED DOMAIN OF HUMAN G ALPHA S LONG ISOFORM | polymer | 229 | 26625.1 | 2 | UniProt (P63092) UniProt (Q5JWF2) Pfam (PF00503) | HOMO SAPIENS (HUMAN) | |
| 3 | E, H (A, B) | N-ETHYL-5'-CARBOXAMIDO ADENOSINE | non-polymer | 308.3 | 2 | Chemie (NEC) | |||
| 4 | F, G (A) | octyl 1-thio-beta-D-glucopyranoside | non-polymer | 308.4 | 2 | Chemie (SOG) | |||
| 5 | I (C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) |
Sequence modifications
A, B: 1 - 308 (UniProt: P29274)
C, D: 26 - 60 (UniProt: P63092)
C, D: 204 - 394 (UniProt: Q5JWF2)
| PDB | External Database | Details |
|---|---|---|
| Ala 154 | Asn 154 | engineered mutation |
| Glu 309 | - | expression tag |
| Asn 310 | - | expression tag |
| Leu 311 | - | expression tag |
| Tyr 312 | - | expression tag |
| Phe 313 | - | expression tag |
| Gln 314 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | - | expression tag |
| Asp 49 | Gly 49 | engineered mutation |
| Asn 50 | Glu 50 | engineered mutation |
| Arg 61 | - | linker |
| Ile 193 | - | linker |
| Tyr 194 | - | linker |
| His 195 | - | linker |
| Gly 196 | - | linker |
| Gly 197 | - | linker |
| Ser 198 | - | linker |
| Gly 199 | - | linker |
| Gly 200 | - | linker |
| Ser 201 | - | linker |
| Gly 202 | - | linker |
| Gly 203 | - | linker |
| - | Asn 897 | deletion |
| - | Met 898 | deletion |
| - | Val 899 | deletion |
| - | Ile 900 | deletion |
| - | Arg 901 | deletion |
| - | Glu 902 | deletion |
| - | Asp 903 | deletion |
| - | Asn 904 | deletion |
| - | Gln 905 | deletion |
| - | Thr 906 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Asp 249 | Ala 892 | engineered mutation |
| Asp 252 | Ser 895 | engineered mutation |
| Asp 272 | Leu 915 | engineered mutation |
| Ala 372 | Ile 1015 | engineered mutation |
| Ile 375 | Val 1018 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 123069.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1676.7 | |
| All* | Total formula weight | 124745.9 |
