5G53
Structure of the adenosine A2A receptor bound to an engineered G protein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | ADENOSINE RECEPTOR A2A | polymer | 314 | 34909.5 | 2 | UniProt (P29274) Pfam (PF00001) | HOMO SAPIENS (HUMAN) | |
| 2 | C, D (C, D) | ENGINEERED DOMAIN OF HUMAN G ALPHA S LONG ISOFORM | polymer | 229 | 26625.1 | 2 | UniProt (P63092) UniProt (Q5JWF2) Pfam (PF00503) | HOMO SAPIENS (HUMAN) | |
| 3 | E, H (A, B) | N-ETHYL-5'-CARBOXAMIDO ADENOSINE | non-polymer | 308.3 | 2 | Chemie (NEC) PubChem (23913416) PubChem (24867503) PubChem (40967901) PubChem (40967902) PubChem (44308232) PubChem (44338050) PubChem (104795) PubChem (50987963) PubChem (686179) PubChem (1254895) PubChem (2868392) PubChem (448222) PubChem (5342881) PubChem (6541320) PubChem (6603839) PubChem (6604901) PubChem (6610317) PubChem (118705485) PubChem (7068779) PubChem (7256363) PubChem (7256365) PubChem (11957539) PubChem (124720172) PubChem (133688337) PubChem (138106599) | |||
| 4 | F, G (A) | octyl 1-thio-beta-D-glucopyranoside | non-polymer | 308.4 | 2 | Chemie (SOG) PubChem (20765008) PubChem (22840433) PubChem (24802438) PubChem (24802439) PubChem (44120068) PubChem (46782626) PubChem (53720324) PubChem (53720325) PubChem (53720326) PubChem (53720327) PubChem (3035440) PubChem (363418) PubChem (446404) PubChem (656909) PubChem (89711063) PubChem (97944776) PubChem (92151891) PubChem (95858717) PubChem (95858718) PubChem (96327603) PubChem (96367497) PubChem (96367498) PubChem (98118655) PubChem (101682121) PubChem (102041106) PubChem (124524845) PubChem (171395924) | |||
| 5 | I (C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) |
Sequence modifications
A, B: 1 - 308 (UniProt: P29274)
C, D: 26 - 60 (UniProt: P63092)
C, D: 204 - 394 (UniProt: Q5JWF2)
| PDB | External Database | Details |
|---|---|---|
| Ala 154 | Asn 154 | engineered mutation |
| Glu 309 | - | expression tag |
| Asn 310 | - | expression tag |
| Leu 311 | - | expression tag |
| Tyr 312 | - | expression tag |
| Phe 313 | - | expression tag |
| Gln 314 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | - | expression tag |
| Asp 49 | Gly 49 | engineered mutation |
| Asn 50 | Glu 50 | engineered mutation |
| Arg 61 | - | linker |
| Ile 193 | - | linker |
| Tyr 194 | - | linker |
| His 195 | - | linker |
| Gly 196 | - | linker |
| Gly 197 | - | linker |
| Ser 198 | - | linker |
| Gly 199 | - | linker |
| Gly 200 | - | linker |
| Ser 201 | - | linker |
| Gly 202 | - | linker |
| Gly 203 | - | linker |
| - | Asn 897 | deletion |
| - | Met 898 | deletion |
| - | Val 899 | deletion |
| - | Ile 900 | deletion |
| - | Arg 901 | deletion |
| - | Glu 902 | deletion |
| - | Asp 903 | deletion |
| - | Asn 904 | deletion |
| - | Gln 905 | deletion |
| - | Thr 906 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Asp 249 | Ala 892 | engineered mutation |
| Asp 252 | Ser 895 | engineered mutation |
| Asp 272 | Leu 915 | engineered mutation |
| Ala 372 | Ile 1015 | engineered mutation |
| Ile 375 | Val 1018 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 123069.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1676.7 | |
| All* | Total formula weight | 124745.9 |
