5FZO

Crystal structure of the catalytic domain of human JmjD1C

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	PROBABLE JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROT EIN 2C	polymer	352	40373.2	1	UniProt (Q15652) Pfam (PF02373)	HOMO SAPIENS (HUMAN)	JUMONJI DOMAIN-CONTAINING PROTEIN 1C, THYROID RECEPTOR-INTERACTING PROTEIN 8, TR-INTERACTING PROTEIN 8, TRIP-8
2	B (B)	PROBABLE JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROT EIN 2C	polymer	352	40401.2	1	UniProt (Q15652) Pfam (PF02373)	HOMO SAPIENS (HUMAN)	JUMONJI DOMAIN-CONTAINING PROTEIN 1C, THYROID RECEPTOR-INTERACTING PROTEIN 8, TR-INTERACTING PROTEIN 8, TRIP-8
3	C, E (A, B)	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
4	D, F (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5	G, H, I (B)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
6	J, K (A, B)	water	water		18.0	502	Chemie (HOH)

Sequence modifications

A: 2157 - 2500 (UniProt: Q15652)

PDB	External Database	Details
Met 0	-	expression tag
Ala 2501	-	expression tag
Glu 2502	-	expression tag
Asn 2503	-	expression tag
Leu 2504	-	expression tag
Tyr 2505	-	expression tag
Phe 2506	-	expression tag
Gln 2507	-	expression tag

B: 2157 - 2500 (UniProt: Q15652)

PDB	External Database	Details
Met 0	-	expression tag
Ala 2501	-	expression tag
Glu 2502	-	expression tag
Asn 2503	-	expression tag
Leu 2504	-	expression tag
Tyr 2505	-	expression tag
Phe 2506	-	expression tag
Gln 2507	-	expression tag
Asp 2340	Ser 2340	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	80774.4
Non-Polymers*	Number of molecules	7
	Total formula weight	367.0
All*	Total formula weight	81141.3

*Water molecules are not included.