5FY8

Crystal structure of human JMJD2A in complex with D-threo-isocitrate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	LYSINE-SPECIFIC DEMETHYLASE 4A	polymer	381	44326.3	2	UniProt (O75164) Pfam (PF02375) Pfam (PF02373) In PDB	HOMO SAPIENS (HUMAN)	JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN 3A, JUMONJI DOMAIN-CONTAINING PROTEIN 2A
2	A, B	NICKEL (II) ION	non-polymer		58.7	2	Chemie (NI)
3	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	A, B	3-carboxy-2,3-dideoxy-D-erythro-pentaric acid	non-polymer		192.1	2	Chemie (N81)
5	A, B	DIMETHYL SULFOXIDE	non-polymer		78.1	2	Chemie (DMS)
6	A, B	1,2-ETHANEDIOL	non-polymer		62.1	7	Chemie (EDO)
7		water	water		18.0	196	Chemie (HOH)

Sequence modifications

A, B: 1 - 359 (UniProt: O75164)

PDB	External Database	Details
Met -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	88652.5
Non-Polymers*	Number of molecules	15
	Total formula weight	1223.2
All*	Total formula weight	89875.7

*Water molecules are not included.