5FWP
Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HEAT SHOCK PROTEIN HSP 90 BETA | polymer | 727 | 83645.5 | 2 | UniProt (P08238) Pfam (PF13589) Pfam (PF00183) | HOMO SAPIENS (HUMAN) | HSP 90, HEAT SHOCK 84 KDA, HSP 84, HSP84, HEAT SHOCK PROTEI N HSP 90 BETA |
| 2 | C (E) | HSP90 CO-CHAPERONE CDC37 | polymer | 378 | 44622.4 | 1 | UniProt (Q16543) Pfam (PF03234) Pfam (PF08565) Pfam (PF08564) | HOMO SAPIENS (HUMAN) | HSP90 CHAPERONE PROTEIN KINASE-TARGETING SUBUNIT, P50CDC37 |
| 3 | D (K) | CYCLIN-DEPENDENT KINASE 4 | polymer | 310 | 34520.6 | 1 | UniProt (P11802) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | CELL DIVISION PROTEIN KINASE 4, PSK-J3 |
| 4 | E, G (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | F, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
A, B: 1 - 724 (UniProt: P08238)
K: 1 - 303 (UniProt: P11802)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Phe 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | expression tag |
| Ala -5 | - | expression tag |
| Met -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Phe 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 246434.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1063.0 | |
| All* | Total formula weight | 247497.0 |
