5FWJ
Crystal structure of human JARID1C in complex with KDM5-C49
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HISTONE DEMETHYLASE JARID1C | polymer | 471 | 54206.8 | 2 | UniProt (P41229) Pfam (PF02373) Pfam (PF21323) Pfam (PF02928) | HOMO SAPIENS (HUMAN) | |
| 2 | C, G, H, M, N (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) | |||
| 3 | D, E, J, K (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | F, L (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 5 | I, O (A, B) | 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid | non-polymer | 306.4 | 2 | Chemie (MMK) | |||
| 6 | P, Q (A, B) | water | water | 18.0 | 607 | Chemie (HOH) |
Sequence modifications
A, B: 8 - 83 (UniProt: P41229)
| PDB | External Database | Details |
|---|---|---|
| Ser 6 | - | expression tag |
| Met 7 | - | expression tag |
| Gly 84 | - | linker |
| Gly 85 | - | linker |
| Gly 86 | - | linker |
| Gly 87 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 108413.6 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1105.8 | |
| All* | Total formula weight | 109519.4 |
