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5FP8

Crystal structure of human KDM4D in complex with 3-4-methylthiophen-2- ylmethylaminopyridine-4-carboxylic acid

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
LYSINE-SPECIFIC DEMETHYLASE 4Dpolymer33438534.61UniProt (Q6B0I6)
Pfam (PF02375)
Pfam (PF02373)
HOMO SAPIENS (HUMAN)JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN 3D, JU MONJI DOMAIN-CONTAINING PROTEIN 2D, HUMAN LYSINE-SPECIFIC DEMETHYL ASE 4D, JMJD2D
2B
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
3C
(A)
COBALT (II) IONnon-polymer58.91Chemie (CO)
4D
(A)
3-[(4-methylthiophen-2-yl)methylamino]pyridine-4-carboxylic acidnon-polymer248.31Chemie (AUY)
5E, F, G, H, I...
(A)
SULFATE IONnon-polymer96.17Chemie (SO4)
6L
(A)
waterwater18.0489Chemie (HOH)
Sequence modifications
A: 11 - 341 (UniProt: Q6B0I6)
PDBExternal DatabaseDetails
Gly 8-expression tag
His 9-expression tag
Met 10-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight38534.6
Non-Polymers*Number of molecules10
Total formula weight1045.1
All*Total formula weight39579.7
*Water molecules are not included.

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PDB entries from 2025-10-15

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